A team from the COR-ITACA and the company Corify Care marks a major breakthrough in cardiac electrophysiology today with the publication of its patented Global Volumetric Mapping technology in the journal Nature Communications Medicine. The publication validates the first system capable of simultaneously mapping the four chambers of the heart, providing physicians with a complete, real-time view of arrhythmias that current solutions cannot offer.

Experts from Hospital General Universitario Gregorio Marañón, Universitat Autònoma de Barcelona, Hospital Clínic de Barcelona–Universitat de Barcelona, IDIBAPS – August Pi Sunyer Biomedical Research Institute, Karlsruhe Institute of Technology, and the Biomedical Research Networking Center for Cardiovascular Diseases (CIBERCV) also participated in this study.

Current mapping systems analyze the heart chamber by chamber, forcing clinicians to infer what they cannot see. Corify Care’s technology, developed in the laboratories of the UPV’s ITACA Institute, changes this paradigm.

This evolution of the Corify system, which previously mapped the heart’s surface, now enables visualization of the interior of the cardiac walls and the septum. Its technology provides a map of the entire heart in a single heartbeat, revealing how arrhythmias move through the cardiac wall and between chambers, before and during ablation.

“It’s about visibility and confidence«, says Andreu Climent, CEO of Corify Care and researcher at UPV. “We give physicians the complete picture from the start, not fragments. A global view means faster decisions, more targeted ablations, and the potential to reduce procedure time and complexity».

Designed for the electrophysiology lab of the future

The Corify Care system uncovers arrhythmia pathways that are often missed by conventional tools, including circuits located deep within the cardiac wall or spanning multiple chambers. By eliminating blind spots, the platform helps physicians address complex cases more efficiently and with greater predictability.

“For the first time, we can see the heart non-invasively exactly as it really behaves: globally”, notes Felipe Atienza, Head of the Cardiology Department at Hospital General Universitario Gregorio Marañón. “This has significant implications for workflow, clinical outcomes, and scalability in electrophysiology laboratories.”

Jorge Vicente-Puig, lead author of the study, adds that this research demonstrates that a volumetric approach is essential for true arrhythmia characterization: “We have overcome past mathematical limitations to deliver a complete physiological 3D image.”

Regulatory status and next steps

The ACORYS® system holds CE marking and is currently under FDA review to meet regulatory requirements in the U.S. market. Corify Care is actively advancing integrations with leading catheter navigation platforms to enable a seamless hybrid workflow and is developing several research lines, including volumetric analysis. These will be presented at the AF Symposium 2026 in Boston.

Reference: Jorge Vicente-Puig, Judit Chamorro-Servent, Ernesto Zacur, Inés Llorente-Lipe, Marta Martínez-Pérez, Jorge Sánchez, Jana Reventos-Presmanes, Ivo Roca-Luque, Lluís Mont, Felipe Atienza, Andreu M. Climent, Maria S. Guillem & Ismael Hernández-Romero. Volumetric non-invasive cardiac mapping for accessible global arrhythmia characterization. Commun Med (2026). https://doi.org/10.1038/s43856-025-01332-5

_{Noticia elaborada por ITACA FORWARD, financiada por Ivace+i Innovación y la Unión Europea a través del Programa Fondo Europeo de Desarrollo Regional (FEDER) Comunitat Valenciana 2021-2027 (Referencia del proyecto: INNVA2/2025/17)}